The invention discloses a method and device for controlling explosion initiation of detonators, and an initiator. The method for controlling explosion initiation of the detonators includes the steps of receiving an initial delay value inputted by a user and an inter-hole delay value inputted by the user, wherein the initial delay value is the delay value of the initial detonator; calculating delay values of other detonators expect the initial detonator according to the initial delay value inputted by the user and the inter-hole delay value inputted by the user; sending detonation signals to the detonators so that the detonators can be detonated when the corresponding delay times are reached. By means of the method, the device and the initiator, the detonation efficiency is improved under the condition of a single hole and the multiple detonators.