The invention provides an automatic layout method and device of flexible cables and relates to the technical field of mechanical engineering. By adoption of the automatic layout method and device, the difficulty that the automatic layout design of large quantity of cables is not easily realized in the prior art is solved. The automatic layout method comprises the following steps of: acquiring information of cable bundles; acquiring position information of first ends of the cables and position information of second ends of the cables; acquiring cable paths according to the information of the cable bundles, the position information of the first ends and the position information of the second ends. The automatic layout method and device provided by the invention have the advantages that automatic generation of the flexible cables on a three-dimensional model of a complex product can be realized, and the design efficiency and the quality of the cable layout are effectively improved.