The invention provides a self-locking self-guide universal liquid driving device, which comprises a liquid driving piston, a piston sealing element, an oil cylinder and an oil cylinder sitting force plate, wherein the outer part of the oil cylinder is connected and matched with a stroke regulating sleeve through screw threads, the upper end parts of the stroke regulating sleeve and the liquid driving piston are respectively in butt joint matching with a universal ball seat, the upper part of the universal ball seat is connected with a ball body press cover, then, a ball-shaped cavity is formed, a ball head of a universal ball is arranged in the ball-shaped cavity, a rod body of the universal ball upwards passes through the ball body press cover and is then fixedly connected with a universal force bearing seat plate, and the outer peripheries of the stroke regulating sleeve and the universal ball seat are provided with a locking mechanism. The self-locking self-guide universal liquid driving device has the advantages that the mode of liquid driving support force, stroke threaded connecting force, universal leveling and self locking position limitation is adopted, an original jack is changed into a liquid driving oil cylinder, an original inclined steel plate is plugged into a gap to be changed into the stroke threaded connecting force, the original press plate fixation is simplified into the locking fixation by a clamp loop, the original leveling operation procedure is thoroughly changed, the structure is compact, the practicability is high, and the efficient use effect of the platform operation drilling platform surface leveling procedure is improved.