The invention relates to compound donkey-hide gelatin slurry and a preparation process thereof. The existing compound donkey-hide gelatin slurry does not have the efficacies of tonifying the kidney and preventing miscarriage, and removing cardiopyrexia for tranquilization. Therefore, the compound donkey-hide gelatin slurry is prepared from raw materials such as donkey-hide gelatin, ginseng, Eucommia ulmoides, lily, prepared rehmannia root and Codonopsis pilosula and trifoliate orange according to a new process. The preparation process of the compound donkey-hide gelatin slurry comprises the steps of firstly immersing the ginseng and radix scrophulariae into 45% ethanol, then adding into a high-pressure alcohol extraction tank, then inflating and pressurizing for the high-pressure alcohol extraction tank to 8-10 kgf/cm<2>, immersing for 2 hours, and then placing into a tank body of a novel traditional Chinese medicine extraction tank. Meanwhile, in the concentration of liquid medicine, a membrane concentration device is preferentially adopted for concentration. The compound donkey-hide gelatin slurry has the efficacies of nourishing yin and tonifying qi, and tonifying blood, patients with constitution with yin deficiency and people with weakness of the spleen and the stomach also can take, the compound donkey-hide gelatin slurry is suitable for various crowds to take, especially for women to take, and the preparation process adopts a new high-normal pressure alcohol extraction/aqueous extraction mixed extraction process for medicine juice raw materials, so that active ingredients of all components are not lost.