A method using a nontoxic initiator for preparation of PVC (polyvinyl chloride) paste resin relates to the field of chemical production, and especially relates to production of the PVC paste resin. The method is as follows: according to certain proportions, taking vinyl chloride monomer, deionized water, an emulsifier and an initiator for homogenization for 5-15 minutes by a homogenization pump to form fine liquid droplets uniform in size, under the action of the initiator, reacting for 6-10 hours at 40-50 DEG C to produce PVC homopolymer latex, and preparing the PVC paste resin by spray drying, grinding, packaging and other processes of the latex.