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发明授权
CN103717742B 免疫原性组合物 有权 复审申请

免疫原性组合物
摘要：
本发明涉及包含来自艰难梭菌的毒素A和/或毒素B的片段的融合蛋白，具体而言，本发明涉及包含第一片段和第二片段的蛋白，其中(v)所述第一片段是毒素A重复结构域片段；(vi)所述第二片段是毒素B重复结构域片段；(vii)所述第一片段具有第一近端；(viii)所述第二片段具有第二近端；并且其中所述第一片段和所述第二片段彼此邻近，并且其中所述多肽诱导中和毒素A或毒素B或两者的抗体。本发明还涉及包含SEQ ID NO:10、SEQ ID NO:11、SEQ ID NO:12、SEQ ID NO:13、SEQ ID NO:14、SEQ ID NO:15、SEQ ID NO:16、SEQ ID NO:17、SEQ ID NO:18、SEQ ID NO:19、SEQ ID NO:28、SEQ ID NO:29、SEQ ID NO:30、SEQ ID NO:31、SEQ ID NO:32、SEQ ID NO:33或SEQ ID NO:34或SEQ ID NO:35的片段或变体的组合物。
摘要（英）：

The present invention relates to fusion proteins comprising fragments from toxin A and/or toxin B of Clostridium difficile, in particular the invention relates to proteins comprising a first fragment and a second fragment, wherein [0205] the first fragment is a toxin A repeating domain fragment; [0206] the second fragment is a toxin B repeating domain fragment; [0207] the first fragment has a first proximal end; [0208] the second fragment has a second proximal end; and wherein the first fragment and the second fragment are adjacent to one another and wherein the polypeptide elicits antibodies that neutralize toxin A or toxin B or both. The invention further relates to compositions comprising fragments or variants of SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:28, SEQ ID NO:29, SEQ ID NO:30, SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33 or SEQ ID NO:34 or SEQ ID NO:35.

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