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发明公开
CN103724424A 一种mPEG-SPA-pGLP-2复合物及其制备方法和应用 有权

一种mPEG-SPA-pGLP-2复合物及其制备方法和应用
摘要：
本发明公开了一种mPEG-SPA-pGLP-2复合物及其制备方法和应用，其由猪胰高血糖素样肽-2（porcineglucagon-likepeptide-2,pGLP-2）与单甲氧基聚乙二醇-琥珀酰亚胺丙酸酯（methoxy-polyethyleneglycol-succinimidyl-propionicacidester,mPEG-SPA）通过加成反应连接构成，所述pGLP-2第30位的Lys与所述mPEG-SPA的末端双键形成共价键而连接；该复合物是通过用弱酸性阳离子交换树脂层析法从修饰混合物中分离得到的单点修饰产物。本发明mPEG-SPA-pGLP-2复合物修饰产物单一，分离纯化简单。
摘要（英）：

The invention discloses an mPEG-SPA-pGLP-2 compound as well as a preparation method and application thereof. The compound is formed by connecting porcine glucagon-like peptide-2 (pGLP-2) and methoxy polyethylene glycol-succinimidyl propionic acid ester (mPEG-SPA) through an addition reaction, wherein the Lys on the 30th site of the pGLP-2 and end double bonds of the mPEG-SPA form a covalent bond to be connected. The compound is a single-point modification product separated from a modified mixture through weak-acid cation-exchange resin chromatography. The mPEG-SPA-pGLP-2 compound is single in modification product and simple in separation and purification.

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