The invention discloses a brewing method of a begonia root wine. The brewing method is characterized by comprising the steps: picking dry and disease-free begonia roots, and performing soaking, pulping, compound enzyme treating, blending, sterilizing, yeast fermenting, filtering, ageing, canning, sterilizing and the like to brew the begonia root wine. According to the brewing method, by adopting a compound enzyme enzymolysis technology, a pectin layer of the begonia roots can be decomposed, more nutritional ingredients can be fully separated out, the utilization rate of a raw material is increased, and thus the finished begonia root wine is thick and strong in taste, mellow in flavor, stable in color, and rich in nutrients, and has health care functions of activating blood and dissolving stasis, stopping bleeding and clearing heat, and the like.