The invention discloses a method for predicting current at neutral points of a transformer during the monopolar operation of a direct current system. The method is characterized in that after an alternating current and direct current transmission network topologic structure chart and system running parameters of the neutral points of the transformer to be detected during the monopolar operation of the direct current system are obtained, the method is implemented by the following steps of 1, calculating the self resistance of direct current grounding electrodes and grounding grids at the neutral points; 2, calculating the mutual resistance of the direct current grounding electrodes and the grounding grids at the neutral points; 3, establishing an alternating current and direct current transmission system model of the neutral points based on the self resistance, the mutual resistance and the alternating current and direct current transmission network topologic structure chart and the system running parameters of the neutral points by utilizing PSCAD (power system computer aided design); 4, running the model to measure current at each neutral point of the transformer as a predicted value. According to the method, the concept of the mutual resistance is disclosed to convert a complex current field problem into an easy-to-solve circuit problem; the model is a visual model, so that a prediction system is more intuitive, and can be conveniently correspondingly modified according to an actual alternating current and direct current hybrid system, and the applicability of the prediction scheme is improved.