The invention belongs to the technical field of histological anatomy, and particularly relates to a three-dimensional visual model of a main fiber composition mesh structure in the human skin. According to the technical scheme, the three-dimensional visual model of the main fiber composition mesh structure in the human skin is obtained through the method which comprises the steps of a, conducting histologic sectioning, b, conducting dying, c, collecting an image, d, conducting image registration, e, conducting image binaryzation processing, and f, conducting three-dimensional reconstruction visualization. The model can be used for three-dimensional printing of the main fiber composition mesh structure in the human skin, biomimetic material preparation, research for the skin physiological function and the like.