The invention relates to a reactor pressure vessel nozzle detection probe frame, comprises a base, a longitudinal frame assembly and a transverse frame assembly, wherein the longitudinal frame assembly is used for detecting a weld joint at the connecting part of the outer end of a nozzle and a safe end and a weld joint at the connecting part of the safe end and a main pipeline; the transverse frame assembly is used for detecting the connecting weld joint of an inner wall overlaying layer of the nozzle and a barrel body and the connecting weld joint of the nozzle and the barrel body; the longitudinal frame assembly and the transverse frame assembly are independent from each other and arranged on the base. The longitudinal frame assembly and the transverse frame assembly are arranged on the base so that the detection on nozzles of a water inlet pipe and a water outlet pipe can be finished when the probe frame enters the water once; when the transverse frame assembly is used for detecting the connecting weld joint of the inner wall overlaying layer of the nozzle and the barrel body and the connecting weld joint of the nozzle and the barrel body, the longitudinal frame assembly is contracted, when the longitudinal frame assembly is used for detecting the weld joint at the connecting part of the outer end of the nozzle and the safe end and the weld joint at the connecting part of the safe end and the main pipeline, the transverse frame assembly is contracted, so that the probe can be effectively from invalid abrading, and the service life of the probe is prolonged.