The invention relates to an explosion venting plate and a manufacturing method of the explosion venting plate. The explosion venting plate comprises a body layer, an explosion venting layer, an internally-arranged surrounding frame, an externally-arranged surrounding frame and a middle structure. A hole is formed in the body layer and is filled with the explosion venting layer. The internally-arranged surrounding frame is arranged on the periphery of the explosion venting layer and separates the explosion venting layer from the body layer. The externally-arranged surrounding frame is arranged on the edge around the periphery of the body layer. The middle structure is arranged between the body layer and the explosion venting layer and used for connecting the internally-arranged surrounding frame with the externally-arranged surrounding frame and supporting the internally-arranged surrounding frame. The space between the internally-arranged surrounding frame and the explosion venting layer is filled with flexible seam filling materials. The explosion venting plate has the explosion venting function, meanwhile has the bearing function, and can be used independently.