The invention discloses a catalytic cracking coupling process for preparing low-carbon olefin and C<5+> hydrocarbon by using an organic oxygen-containing compound. The catalytic cracking coupling process comprises the following steps: converting the organic oxygen-containing compound into the low-carbon olefin under the effect of a catalyst in a reactor for preparing the low-carbon olefin by the organic oxygen-containing compound; in a catalyst regenerator, heating for oxidizing and decarbonizing a waste catalyst which enters the catalyst regenerator through a waste catalyst conveying pipeline from the reactor so as to regenerate a regenerated catalyst; conveying the regenerated catalyst back into the reactor by a regenerated catalyst conveying pipeline; introducing the C<5+> hydrocarbon into the regenerated catalyst conveying pipeline; under the catalytic effect of the catalyst, catalytically cracking the C<5+> hydrocarbon into the low-carbon olefin; and conveying the generated low-carbon olefin and the regenerated catalyst into the reactor by the regenerated catalyst conveying pipeline. According to the process disclosed by the invention, the high temperature of the regenerated catalyst is effectively utilized and the C<5+> hydrocarbon is cracked into the low-carbon olefin to form active hydrocarbon tank species, so as to shorten a reaction induction period, reduce the selectivity of converting the organic oxygen-containing compound into active carbon tank species and improve the yield of the low-carbon olefin.