The invention relates to the field of interdiscipline of biomedical engineering and electronic sensor technology, and particularly relates to a device for early-stage rapid portable detection of canceration cells. The detection device comprises two polydimethyl siloxane micro-film capacitance biosensors, a data measurement system, a data transmission system and a PC (Personal Computer), wherein the two polydimethyl siloxane micro-film capacitance biosensors are arranged in parallel, and data processing software is installed on the PC. The detection device is used for completing lesion detection and monitoring by detecting the surface stress of the canceration cell characterized by capacitance and comparing the surface stress of the canceration cell with the surface stress of a normal human body cell. The detection device provides a brand-new idea and a solution for the early-stage detection of cancers, has the characteristics of high sensitivity, good stability, rapid response (lower than 5 minutes), simple structure, simplicity and easiness in operation, low cost and the like, relatively high application value and good development prospect. The application of a Zigbee technology is a useful attempt and supplement for internet of things.