The invention provides application of germanium-based graphene in osteogenesis promotion. Germanium-based graphene can obviously promote the early alkaline phosphatase expression and late osteocalcin expression of bone narrow mesenchymal stem cells, and has the capability of obviously promoting the osteogenic differentiation of bone narrow mesenchymal stem cells; germanium-based graphene can be loaded on the surface of an implant with hard tissue, and then the implant can be implanted into a human body or animal body, so as to promote osteogenesis, improve the applying effect, promote osseointegration between the implant and bones, and promote the formation of new bones. Also, germanium-based graphene can be used as an osteogenesis promotion component to prepare drugs for treating bone defects or osteoporosis. In addition, germanium in germanium-based graphene has an anti-cancer anti-aging health-care function.