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发明公开
CN103820455A 一种肺组织特异性TITF1启动子及其应用 失效 - 权利终止

一种肺组织特异性TITF1启动子及其应用
摘要：
本发明属于生物技术领域，涉及一种肺组织异性TITF1启动子及其应用，特别提供了一种肺组织特异性表达基因5′调控区特异性启动子及其在转基因猪中的应用，该启动子只在肺组织中具有启动特性，而在除肺组织外的多种细胞中均无启动活性，可见该基因启动子只在肺组织中特异性地启动下游基因的表达，因此能够满足目的基因在肺组织中特异性表达的要求，为通过转基因技术来提高猪的抗病品质提供了一种重要的元件。
摘要（英）：

The invention belongs to the technical field of biology, relates to a lung tissue specificity TITF1 promoter and application thereof, and in particular provides a lung tissue specificity expressed gene 5' control region promoter and application thereof in a transgenosis pig. The promoter has activation characteristic only in a lung tissue, and has no activation characteristic in various cells except the lung tissue, so that the gene promoter can only specifically activate downstream gene expression in the lung tissue; therefore, the gene promoter can satisfy the requirement of specific expression of a target gene in the lung tissue; an important component for improving disease-resistant quality of the pig through transgenosis technology is provided.

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