The invention discloses a mode-adjustable intaglio printing air-conditioning system device and a using method. The mode-adjustable intaglio printing air-conditioning system device comprises a case, wherein a forced draught blower section, a dry steam humidification section, a surface-cooling dehumidification section, an intermediate-acting filtering section, a fresh air and return air mixing section, an air exhausting section and an air exhausting and returning section are sequentially arrayed in the case; and the air-conditioning system device can be in an all fresh air state, an all return air state or a proportionally-mixed return air state in an adjustable manner. By using the mode-adjustable intaglio printing air-conditioning system device, different requirements of an intaglio press on air all the year round are met. By using the mode-adjustable intaglio printing air-conditioning system device, humidification is performed in a dry season, dehumidification is performed in a plum rain season, cooling is performed in a hot summer, air with high solvent content is exhausted, and air taken away by negative pressure of the press is supplemented.