The invention provides a four-segmentation comprehensive automation transformer substation with two main transformers. The transformer substation comprises two 35 KV incoming lines, the two main transformers, four segmented 10 KV buses, a capacitor and a voltage reduction transformer. The high voltage ends of the two main transformers are connected with the two 35 KV incoming lines through circuits respectively, and the two main transformers output 10 KV power supplies through voltage reduction low voltage ends. The four segmented 10 KV buses are connected with the low voltage ends of the two main transformers through circuits respectively. The capacitor is connected to the 10 KV buses through circuits. The voltage reduction transformer is connected to the 10 KV buses through circuits. The four-segmentation comprehensive automation transformer substation replaces a burn-in device in the transformer substation and meets the requirement for modernized control and operation of a modern power grid, safety and stability of the power grid are improved, running reliability of the device is improved, the intelligent level of the power grid is increased, the four-segmentation comprehensive automation transformer substation is simple in system structure and can be implemented in an existing transformer substation, no land needs to be additionally occupied, and cost is saved.