The invention discloses a formula of persimmon special-purpose mixed fertilizer prepared by matching of calcium-magnesia phosphate powder and fertilizer sources such as single superphosphate particles and urea. According to a persimmon fertilization requirement rule, calcium-magnesia-phosphate fertilizer powder and fertilizer sources such as single superphosphate particles and urea are matched so that a calcium-magnesia-phosphate film is formed on surface of the particle and thus deliquescence of single superphosphate and urea because of direct contact is prevented. After being used in soil, the persimmon special-purpose mixed fertilizer has effects of reducing phosphorus immobilization and slowly releasing nitrogen. The calcium-magnesia phosphate fertilizer contains medium trace elements necessary for crop growth and is ideal multi-element compound fertilizer. A preparation method of the persimmon special-purpose mixed fertilizer comprises matching 0.9-1.1 parts of high-quality calcium-magnesia phosphate fertilizer powder with 4.4-4.6 parts of urea, 0.9-1.1 parts of monoammonium phosphate, 1.9-2.1 parts of single superphosphate particles and 1.4-1.6 parts of potassium chloride, carrying out dry-mixing stirring and carrying out split charging by bags. The persimmon special-purpose mixed fertilizer can be marketed and be used for production. The persimmon special-purpose mixed fertilizer contains 40% of the total nitrogen, phosphorus and potassium nutrients and has a nitrogen-phosphorus-potassium ratio of 22: 9: 9.