The invention provides an integrated automation transformer substation. A first 35kV inlet wire is communicated with a first 35kV inlet wire switch, a No.1 main transformer, a first 10kV main transformer switch, a 10kV first section bus and a plurality of outlet wires thereof, a second 35kV inlet wire is communicated with a second 35kV inlet wire switch and a No.2 main transformer, then is communicated with a second 10kV main transformer switch, a 10kV second section bus and a plurality of outlet wires thereof, a third 10kV main transformer switch, a third section bus and a plurality of outlet wires thereof respectively, a first section switch and a lead are arranged between the first section bus and the second section bus, a third 35kV inlet wire is communicated with a third 35kV inlet wire switch, a No.3 main transformer, a fourth 10kV main transformer switch, a 10kV fourth section bus and a plurality of outlet wires thereof, a second section switch and another lead are arranged between the third section bus and the fourth section bus, and a transformer for a first station and a transformer for a second station are connected with the second section bus and the fourth section bus respectively through corresponding transformer switches for the stations, so as to supply power to the whole transformer substation. The integrated automation transformer substation can adapt to the controlled operation requirement of modern transformer substation, and improve the equipment operation reliability and the intelligent level of a power grid.