The invention discloses a preparation method of squalene and beta-carotene composition liquid proliposomes and a method for reducing free radical and harm by adopting proliposomes. The liquid proliposomes is prepared through 5 to 10 parts of phospholipid, 5 to 10 parts of stabilizer, 8 to 15 parts of surface active agent, 20 to 40 parts of squalene and beta-carotene composition and the balance of water. The liquid proliposomes is placed into a hollow cylinder body with two ends being respectively provided with a waterproof and dustproof ventilate membrane, the hollow cylinder body is arranged in a cigarette filter tip of cellulose acetate fibers in the molding process of the cigarette filter tip to obtain a cigarette filter tip capable of reducing the harm of the cigarette, when a consumer smokes the cigarette, the smoke passes through the built-in liquid proliposomes, since the surface area of the liquid proliposomes is large, antioxidant is adequately contacted with mainstream smoke, so that the gas-phase free radical in the mainstream smoke can be effectively eliminated, and powerful technical support can be provided for solving the smoking and health problem.