The invention discloses a different power supply region feeder automation collocation method based on a wiring mode. The method comprises the following steps that 1, different power supply subregions are combined, different wiring modes and feeder lines are adopted to calculate reliability promoting levels which are brought after automatic allocation schemes of different levels are adopted; 2, the electric price levels of the power supply subregions to which the feeder lines belong are combined to calculate the economic benefit level brought by increased power supply volume after the reliability is promoted; 3, the social benefit brought by the increased power supply volume is analyzed through the region unit electric quantity GDP (Gross Domestic Product) production value level; 4, the investment benefit ratio of each feeder line automation configuration mode is calculated; 5, the feeder line automation configuration mode which is most suitable for each power supply subregion is obtained, and the most adaptive feeder line automation configuration is carried out on each power supply subregion. A layering collocation mode is provided by combing with different feeder line wiring modes, the reliability and the economy of the feeder lines are effectively improved, and the larger promotion of the reliability of a weak power grid is favorably realized by automation low input.