The invention discloses an alternation type flow instrument durability experimental facility. The alternation type flow instrument durability experimental facility comprises at least one water tank, at least one water pump matched with the at least one water tank, a first experimental pipeline and a second experimental pipeline, wherein a plurality of instruments to be tested are arranged in the first experimental pipeline, and a plurality of instruments to be tested are arranged in the second experimental pipeline. According to the alternation type flow instrument durability experimental facility, the design that two water supply systems and the two experimental pipelines are combined is adopted; during a whole durability test, the two sets of water supply systems are kept to be in a stable operating condition and are prevented from being impacted by an abrasion test, the reliability of the test is guaranteed, and the service life of equipment is guaranteed; meanwhile, the instruments to be tested can be converted to be in different operating states rapidly, high abrasion strength is achieved, and both the temperature alternation mode and the flow alternation mode are achieved.