The invention discloses a multi-cycle generation scheduling coordinated optimization and closed-loop control method which comprises the following steps that first, a monthly generation schedule is made; second, a day-ahead generation schedule is made; third, an intra-day rolling schedule is made; fourth, AGC determines units which only bear basic power through unit classification, and the units which only bear basic power track the intra-day rolling schedule to achieve closed-loop control; fifth, actual operation data of the units are fed back to the monthly generation schedule, and the monthly generation schedule is corrected in a rolling mode. The multi-cycle generation scheduling coordinated optimization and closed-loop control method for the operation plan field is achieved, overall resource optimized allocation and safety constrained control on a longer time dimension are achieved, and the scheduling target for impartiality and openness plus energy conservation at the same time is achieved.