The invention discloses a cultivation method capable of preventing blotchy ripening fruits of tomatoes. After the tomatoes are planted in fields and when the second clusters of fruits grow to be as big as 1-2 cm, a monopotassium phosphate solution with the mass concentration of 0.2-0.3% is sprayed on leaves; when the second clusters of fruits grow to be as big as 1-2 cm, amino acid chelate iron liquid with the mass concentration of 0.05-0.1% is irrigated to roots; when the fourth clusters of fruits grow to be as big as 1-2 cm, a monopotassium phosphate solution with the mass concentration of 0.2-0.3% is sprayed on leaves; after the fifth clusters of fruits grow, a monopotassium phosphate solution with the mass concentration of 0.3% is sprayed on leaves once every other cluster of fruits according to the number of reserved fruit clusters. The cultivation method capable of preventing blotchy ripening fruits of tomatoes can keep the carbon-nitrogen ratio inside tomato plants at the best level, is low in blotchy ripening fruit occurrence rate, is good in fruit commodity, and is high in yield.