The invention discloses an industrial production method of high isotactic polybutylene and a device for implementing the method. The production method comprises the process flows of carrying out bulk polymerization on a liquid-phase butylene-1 monomer in a polymerization kettle at the temperature of 10 DEG C below zero to 70 DEG C above zero to synthesize isotactic polybutylene, and recovering part of unreacted butylene-1 into a butylene gasometer through primary pressure reduction after polymerizing for a certain period of time; then, transferring high isotactic polybutylene from the polymerization kettle to a flash distillation kettle, carrying out reduced-pressure flash distillation, and further recovering the unreacted butylene-1 monomer into the butylene gasometer; sequentially introducing nitrogen gas and air into the flash distillation kettle to replace, discharging a granular high isotactic polybutylene product through an emptying valve at the bottom of the kettle, and packaging. The device comprises a proportioning system, a polymerization system, a gas distribution system, a vacuum nitrogen system, a degassing and flash distillation system and a utility system. Through the industrial production method and the device, the industrial synthesis of the high isotactic polybutylene can be realized, and no organic solvents, waste gases, waste water and waste residues are discharged; in addition, the industrial production method belongs to a green and clean production process.