The invention provides a seminal plasma compound quality control product which comprises freeze-dried powder prepared by mixing a quality control preserving fluid and a seminal plasma stock solution, wherein the quality control preserving fluid is a water solution containing 0.47-0.67 percent of sugar, 0.07-0.17 percent of salt and 0.63-0.83 percent of enzyme stabilizing agent; the seminal plasma stock solution is seminal plasma obtained by directly centrifuging human fresh seminal fluid which is completely liquefied; a mixing volume ratio of the quality control preserving fluid to the seminal plasma stock solution is (1:100)-(100:1). According to the seminal plasma compound quality control product, a special quality control preserving fluid is adopted and freeze-dried after being mixed with the seminal plasma in a proper volume ratio, and then various biochemical criterions in the seminal plasma are more stable, thus the defects of instability and difficulty in preservation of materials in the seminal fluid in vitro are effectively prevented; the prepared seminal plasma compound quality control product is stable in performance, is simple and convenient to use, and can be used in quality control of seminal plasma biochemical detection items.