A system and method for two-level centralized deployment power supply voltage automatic collection are provided and belong to the technical field of power system automatic monitoring. Real-time collection and transmission, and unified storage and service application of voltage data are achieved by the system and the method thereof through using a three-layer system framework including a device layer, an access layer and a main station layer, and a main monitoring station is deployed in a centralized mode on two levels including province-level electric power companies and a headquarter. Existing voltage data in service systems such as a scheduling system and a marketing system, etc. can be fully used by the system and the method, and stability of the system core is ensured while data access in a heterogeneous system can be adapted, resources in communication and information being saved. Moreover, safety access for voltage data to an electric power information internal network can be achieved by loading a security chip in a device which is cooperative with a province-level safety access platform and utilizing strategies such as identity authentication, encrypted transmission, and access control, etc.