The invention relates to an efficient disinfectant special for livestock and poultry, a preparation method and application thereof, and particularly relates to a disinfectant for epidemic prevention of foot-and-mouth disease of the livestock and poultry, and the efficient disinfectant is characterized by being prepared from lime, garlic, sulfur, cordate houttuynia, herba portulacae, realgar and borneol in the weight ratio of 1:1:1:2:1.5:0.1:0.05 by adding water. The efficient disinfectant has good prevention and disease spread inhibition effects on the foot-and-mouth disease of the livestock and poultry.