The invention relates to an intelligent shoe sole cleaning machine which comprises a base and a cover plate covering the base. A cleaning device comprises a brush plate fixture and a cleaning brush plate clamped in the brush plate fixture. An electric driving and transmission device comprises a power supply circuit, a drive motor, a rocker arm, a first cardan joint, a second cardan joint and a transmission shaft. An output shaft of the drive motor is fixed to one end of the rocker arm in a threaded connection mode. The other end of the rocker arm is in threaded connection with one end of the first cardan joint. The other end of the first cardan joint is fixed to one end of the transmission shaft in a threaded connection mode. The other end of the transmission shaft is sleeved with the second cardan joint. The intelligent shoe sole cleaning machine further comprises an inductor and a control circuit. According to the intelligent shoe sole cleaning machine, the rocker arm is in linkage with a cardan joint transmission device, and then the cleaning brush plate is driven to work; in this way, the intelligent shoe sole cleaning machine is simple in structure, low in cost and capable of cleaning shoe soles in both a dry mode and a wet mode, thereby greatly improving the cleaning effect.