A material homogenization method in production of polyvinyl chloride paste resin comprises the following steps: adding all materials into a premixing tank, stirring the materials in the premixing tank by a premixing tank stirrer for 50-70min, starting a dispersion pump, allowing the materials dispersed by the dispersion pump to enter a homogenizer, allowing fine materials homogenized by the homogenizer to enter a rapid operation blind plate, carrying out rapid operation blind plate dispersion, returning to the premixing tank, carrying out multi-time cycle homogenization, and adding the obtained mixture to a polymerization kettle. The use of the material homogenizer substantially shortens the homogenizing time and makes homogenized liquid drops fine and have a narrow particle size distribution width, and product particles are uniform and structured, and satisfy polyvinyl chloride paste resin production requirements, so the product quality and the production efficiency are improved.