The invention relates to a fiber manufacture method, and especially relates to a Ce-doped quartz scintillation fiber manufacture method based on a sol-gel technology. The method comprises the following steps: 1)preparing a solution A according to the proportion configuration of tetraethoxysilane to absolute ethyl alcohol to deionized water at 1: 3: 0.6, dissolving cerium nitrate in ethanol to form a solution B, mixing the solution A and the solution B; and 2)heating the above mixing solution by silicone oil bath to the temperature of 40 DEG C and keeping for 10-20 days, fully hydrolyzing the tetraethoxysilane, wherein the mole percentage of cerium ion to silicon ion in the mixing solution is 0.05-0.2mol%, gelating the mixing solution and drying, and dehydrating to obtain the xerogel particles, and keeping the magnetic stirring during a heating process. The manufacture method realizes the fiber and inorganic performance of the scintillation material, has the advantages of simple and feasible process, and low manufacture cost, and provides possibility for long distance real time-radiation sensing under many scurviness environment.