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发明公开
CN103961685A 一种用于脓毒症治疗的T-肽免疫调节剂 有权

一种用于脓毒症治疗的T-肽免疫调节剂
摘要：
本发明涉及一种用于脓毒症治疗的T-肽免疫调节剂；所述调节剂的结构为(Thr-Lys-Pro-Arg-AAN)4-(Lys-AAN)2-Lys-AAN，其中N为自然数，本发明通过动物实验研究发现，T-肽具有调节效应性T细胞增殖、分泌功能，以及通过结合调节性T细胞表面分子神经纤毛蛋白-1(neuropilin-1，Nrp-1)缓解调节性T细胞负向免疫调控作用。所述的T-肽能够通过上述机制缓解脓毒症引起的免疫抑制状态，特别是细胞免疫抑制，进而达到改善脓毒症小鼠生存率以及脓毒症症状的作用，可以用于脓毒症的治疗。
摘要（英）：

The invention relates to a T-peptide immunomodulator for treating sepsis. The immunomodulator adopts the structure of (Thr-Lys-Pro-Arg-AAN)4-(Lys-AAN)2-Lys-AAN, wherein N is a natural number. According to the immunomodulator, through animal experiment researches, the fact that T-peptide has functions of modulating proliferation and secretion of effector T cells and can relieve the negative immunoregulationeffect of regulatory T cells through combination of Nrp-1 (neuropilin-1) of surface molecules of the regulatory T cells is discovered. The T-peptide can relieve the immunosuppression state caused by the sepsis through the mechanism, particularly the cellular immunosuppression, so that the survival rate of sepsis mice can be increased, sepsis symptoms can be improved, and the T-peptide immunomodulator can be used for treating the sepsis.

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