A slurry-bed reaction equipment comprises a reaction apparatus (101) and a separation apparatus (6) located outside of the reaction apparatus (101). The separation apparatus (6) is in flow communication with the reaction apparatus (101) and located downstream of the reaction apparatus (101). The separation apparatus (6) includes at least one separator (11) and a condensation region (15), and at least a part of the separator (11) is located in the condensation region (15) for enhancing the separation by condensation. A method for conducting a slurry-bed reaction using the reaction equipment is also provided.