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发明公开
CN103966174A 一种重组人3型腺病毒及其制备方法和应用 有权 转让

一种重组人3型腺病毒及其制备方法和应用
摘要：
本发明公开了一种以人3型腺病毒(HAdv3)为载体的人3型、7型腺病毒双价疫苗候选株及其制备方法。人3型腺病毒(HAdv3)衣壳中包含HAdv3六邻体和HAdv7六邻体两种六邻体。在人3型腺病毒基因组E3区插入了HAdv7六邻体蛋白表达框，在体外细胞中拯救包装得到一种六邻体嵌合型的重组腺病毒，其衣壳中包含HAdv3六邻体和HAdv7六邻体两种六邻体。该疫苗候选株灭活或不灭活都可以诱导出同时抗HAdv3和抗HAdv7的中和作用抗体，利用该疫苗候选株可制备预防HAdv3和HAdv7感染的双价疫苗。
摘要（英）：

The invention discloses a novel human adenovirus 3 and 7 bivalent vaccine candidate strain with human adenovirus 3 (HAdv3) as a carrier, and a preparation method thereof. The capsid of the HAdv3 includes an HAdv3 hexon and an HAdv7 hexon. An HAdv7 hexon protein expression cassette is inserted to human adenovirus 3 genome E3 region, rescued packaging is carried out in in-vitro cells to obtain a hexon chimeric recombinant adenovirus, and the capsid of the hexon chimeric recombinant adenovirus includes an HAdv3 hexon and an HAdv7 hexon. The inactivated or non-inactivated vaccine candidate strain can induce an anti-HAdv3 and anti-HAdv 7 neutralization effect antibody, and can be used for making bivalent vaccines for preventing the EV71 infection and the HAdv3 infection.

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