The invention discloses a winding wire of a high-temperature-resistance electromagnetic coil and a manufacturing method of the winding wire. The winding wire comprises a copper conductor, a nickel layer is formed outside the copper conductor in an electroplating manner, an adhesive layer is arranged on the exterior of the nickel layer, a biphenyl type polyimide film wraps the adhesive layer to form a first wrapping layer, a layer of glass fibers wraps the first wrapping layer to form a second wrapping layer, and a layer of biphenyl type polyimide paint coats the second wrapping layer to form an enamel covering layer. According to the winding wire of the high-temperature-resistance electromagnetic coil, the biphenyl type polyimide film and the biphenyl type polyimide paint with the best temperature resistance are taken as an organic insulating layer with a total polyimide (PI) structure; the glass fibers are utilized as an inorganic insulating layer; therefore, by virtue of a hybrid organic and inorganic insulation structure, the high temperature resistance, high radiation resistance, high insulation property and high tensile strength of the winding wire are ensured, the bar-position driving electromagnetic coil manufactured by the winding wire still can stably work for a long term in a high temperature environment at about 320 DEG C after a forced ventilation cooling system is omitted.