The invention discloses a medicinal liquor composition capable of reducing weight and blood uric acid and preventing occurrence of coronary heart disease and cerebral apoplexy, and particularly relates to medicinal liquor made from edible plants serving as raw materials and a preparation process thereof. The medicinal liquor is prepared from the following components: 50-150g/L of raw ginger, 45-120g/L of onion, 45-120g/L of fingered citron and 45-120g/L of kudzu vine root. The invention also provides a preparation method and process of the medicinal liquor composition. After the medicinal liquor is applied continuously, body weight can be reduced, dyslipidemia can be regulated, and factors closely related to blood uric acid can be reduced, so that the blood uric acid can be effectively reduced, occurrence of gout can be prevented, and occurrence of coronary heart disease and cerebral arterial thrombosis can be prevented and treated. The medicinal liquor has the functions of activating blood circulation to remove stasis, reducing body weight and fat, reducing triglyceride and cholesterol and protecting heart and brain from ischemic injury, is comfortable in taste and good in compliance, and can be applied to medicaments for preventing and treating obesity, hyperuricemia, coronary heart disease and cerebral apoplexy.