The invention relates to an Acalypha australis L. and fluoroquinolone antibacterial medicine containing compound medicine for livestock and poultry. The compound medicine comprises the following raw materials in parts by weight: 3-30 parts of fluoroquinolone antibacterial medicine and 5-200 parts of Acalypha australis L, wherein the fluoroquinolone antibacterial medicine is norfloxacin, ciprofloxacin or levofloxacin. Studies prove that after Acalypha australis L. is added to the antibacterial medicine, the resistance of bacteria to the antibacterial medicine can be reversed, thus improving the treatment effects of the antibacterial medicine. By preparing the compound medicine into powder, tablets, oral liquid or granules according to conventional methods and adding the compound medicine to feeds for livestock and poultry according to the additive amount of 0.1-7g of main medicine/kg of feed to feed the livestock and poultry, the medicine cost and the medicine residues can be substantially reduced, higher economic benefits can be created for farmers, and food safety is simultaneously ensured.