The invention provides an anti-blue light nanometer composite monomer material and anti-blue light optical resin prepared from the anti-blue light nanometer composite monomer material. The monomer material comprises a macromolecular monomer, core-shell type transition metallic oxide nanoparticles dispersed in the macromolecular monomer and an ultraviolet absorbent, wherein the total quantity of the nanoparticles accounts for 0.2%-2% of the total weight of the monomer, and the total quantity of the ultraviolet absorbent accounts for 0.5%-5% of the total weight of the monomer; the particle sizes of the nanoparticles are 20-50nm; and a shell is a surface active agent, and the thickness of the shell is 3-10nm. The anti-blue light nanometer composite monomer material can be used for preparing the high-performance anti-blue light nanometer composite optical resin material through a conventional polymerization technology; and the high-performance anti-blue light nanometer composite optical resin material can be used for efficiently and durably shielding high-energy harmful blue light and ultraviolet light with wavelengths of 380-450nm, has excellent combination properties and can be widely applied to the fields of optical protective materials such as blue light protection lenses, LED (Light Emitting Diode) display screen protective films, LED lamp protective films, automobile lamps and optical protective glass.