The invention discloses a heat pump cold-end heat radiation type sealed dehumidification drying house which comprises a drying room, a dehumidification return heat room and a heating room, wherein the air inlet side of the dehumidification return heat room is connected with the drying room, the air outlet side of the dehumidification return heat room is connected with the heating room, and the air outlet side of the heating room is connected with the drying room. A dehumidification coil located on the air inlet side of the dehumidification return heat room and a heat recovery coil located on the air outlet side of the dehumidification return heat room are built in the dehumidification return heat room, the dehumidification coil is in series connection with a refrigerant pipeline of the heat recovery coil, the outlet end of the dehumidification coil in series connection with the refrigerant pipeline of the heat recovery coil is further connected with an outward radiator, and a flow controller is arranged in a heat pump cold water circulating pipeline. The drying house achieves the outward natural heat radiation effect through matching of the dehumidification coil and the heat recovery coil in the dehumidification return heat room, matching of the radiator and a hot air coil and a refrigerant at a heat pump cold-end dehumidification section and accordingly achieves energy saving.