The invention belongs to the technical field of a packaging material, and particularly relates to a flexible color printing composite packaging material and a production process thereof. The flexible color printing composite packaging material consists of a PE (polyethylene) printing film layer, a printing pattern layer, an adhesive layer and a milky white PE film layer which are sequentially distributed, and the packaging material is characterized in that patterns are printed on the inner surface of a transparent film through an internal printing way, the safety risk of the ink pollution can be thoroughly prevented, the printing saturation and fineness can be improved, and the reliable sealing strength is also realized under the high-speed packaging condition. The production process comprises the steps of film production, printing, compounding, curing, coiling and the like. Two layers of PE are compounded, a corona layer and a printing layer are compounded between the two PE layers, the inner surface and the outer surface of the packaging material are respectively a heat sealing layer, so that a good heat sealing property under the high-speed packaging condition can be guaranteed. The printing ink is compounded in the material, the ink is not contacted with exterior, the ink dropping risk and the product pollution risk can be completely prevented, and sanitation and safety can be realized.