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CN104016953A 一类二萜化合物的制备方法及其在抗肿瘤药物中的应用 无效 - 撤回

一类二萜化合物的制备方法及其在抗肿瘤药物中的应用
摘要：
本发明公开了一类二萜化合物的制备方法及其在抗肿瘤药物中的应用。本发明提供了从北部湾柳珊瑚Anthogorgia caerulea中提取分离得到2个新的二萜化合物，它们的结构如式(1)所示，分别命名为Anthogonoid A(1)和Simplexin J(2)。化合物1-2的活性测试结果表明，化合物1和2对人宫颈癌细胞HeLa，人乳腺癌细胞MCF-7，小鼠黑色瘤细胞B16，人肝癌细胞HepG2具有明显的生长抑制活性。本发明的二萜化合物具有抑制多种恶性肿瘤细胞生长的活性，因此在制备抗肿瘤药物方面有良好的前景，为开发利用我国海洋药用资源提供了科学依据。
摘要（英）：

The invention discloses a preparation method and an application of diterpene compounds in antitumor medicines. The two novel diterpene compounds are obtained in an extraction and separation manner from Anthogorgia caerulea in Beibu Gulf. The two novel diterpene compounds have structures shown as the formula (1) and are respectively named as Anthogonoid A (1) and Simplexin J (2). The active testing of the compounds 1-2 shows that the compound 1 and the compound 2 have obvious growth inhibitory activities to human cervical carcinoma cells HeLa, human breast cancer cells MCF-7, black tumor cells B16 in mice and human hepatoma cells HepG2. The diterpene compounds have the activities for inhibiting the growth of a plurality of malignant tumor cells, thereby having good prospects in preparation of the antitumor medicines and providing a scientific basis for development and utilization of marine medicinal resources in China.

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