The invention discloses a CPE inhibition method in an OFDM system and belongs to the field of communication technology. Regarding the shortcoming that the algorithm estimated accuracy of an existing CPE time domain compensation scheme is limited due to the fact that a CP is influenced by interference of a channel environment and the CP is consumed in confronting channel multipath delay and the shortcoming that performance of an existing CPE frequency domain compensation algorithm is limited by OFDM pilot frequency amount. According to the scheme, the CP of time domain and pilot frequency of frequency domain are adopted to serve as effective information to respectively conduct estimation and compensation on CPE, accuracy of the CPE time domain compensation scheme is achieved, and the problem of conflict between bandwidth efficiency and performance in an MMS algorithm is solved. A simulation result shows that when the pilot frequency amount is little, compared with the MMS algorithm, the performance of the CPE inhibition method with the combination of the time domain and the frequency domain is improved by 1dB.