The present invention discloses a composition with a multiplying effect and capable of curing anemia, increasing irony supplement, and alleviating menstrual pain. The composition mainly comprises four abstracts, namely angelica sinensis, ligusticum wallichii, radix paeoniae alba, and prepared rehmannia root, and takes ferrous bisglycinate chelate as an active component. The four abstracts and ferrous bisglycinate chelate are combined on ratio to generate a multiplying effect, and thereby forming the composition. The composition is especially useful for females having iron-deficiency anemia, and is capable of providing irony for female to absorb thereby improving a multiplying effect of hemoglobin concentration, and alleviating menstrual pain.