The invention relates to a guide dike for use in channel improvement engineering, in particular to a caisson-type mobile guide dike and an application method thereof. The caisson-type mobile guide dike comprises a caisson body, a grille, side water injection holes, top drain holes, and interior water holes. The caisson body serves as a body of the caisson-type mobile guide dike; the side water injection holes are arranged in the periphery of the caisson body; the closed end face of the caisson body is provided with the top drain holes which penetrate an inner cavity of the caisson body; the grille is disposed in the inner cavity of the caisson body; the inner cavity of the caisson body is divided into independent spaces; each independent space corresponds to the corresponding side water injection holes; the grille is provided with the interior water holes. the edge of the lower end face of the caisson body and the edge of the bottom of the caisson body are provided with two chamfers which protrude out; the chamfers are parallel to each other; accordingly, the area of contact of the installed caisson-type mobile guide dike with a dike foundation is enlarged, stress dispersion is uniformized, and the impact of stress concentration upon a dike body is avoided.