The invention discloses a device for oxidizing I<-> type primary battery by Cu<2+> and a manufacturing method of the device. The device comprises a waxed egg shell with a hole at the top, the lateral side of the waxed egg shell is provided with a small hole, wax and egg shell of the small hole are removed, and only a semipermeable membrane in the egg shell is left. The waxed egg shell is disposed in a small beaker, copper sulfate solution is filled in the small beaker, the liquid level of the copper sulfate solution is lower than the top of the waxed egg shell, and potassium iodide solution is filled in the waxed egg shell. Two copper sheets are soaked in the copper sulfate solution in the small beaker and the potassium iodide solution in the waxed egg shell respectively and are parallelly connected with a voltmeter and a microammeter through leads. A common semipermeable membrane of eggs substitutes for conventional potassium chloride-agar jelly salt bridge, which is capable of isolating the two different kinds of electrolyte solution and providing passages for ion movement, so that the purpose of oxidizing the I<-> type primary battery by Cu<2+> is achieved.