The invention provides a mineral separation mixing generator. The mineral separation mixing generator comprises a cylindrical shell, wherein the shell is internally and axially provided with an ore pulp pipe; an annular cavity is formed between the inner wall of the shell and the outer wall of the ore pulp pipe; the ore pulp pipe is internally provided with a feeding cavity and a discharging cavity along the axial direction; the outlet of the feeding cavity is communicated with the inlet of the discharging cavity; each of the feeding cavity and the discharging cavity is in a conical structure with large outside and small inside; the diameter of the inlet end of the feeding cavity is equal to the diameter of the inlet end of the discharging cavity; the shell and the side part of the ore pulp pipe are correspondingly provided with gas and medicine liquid inlets along the radial direction; the connection part of the feeding cavity and the discharging cavity is communicated with the gas and medicine liquid inlets; the gas and medicine liquid inlet of the side part of the ore pulp pipe is in a conical structure with large outside and small inside. The mineral separation mixing generator is simple in structure and scientific in principle; ore pulp, air and medicaments are sufficiently mixed to generate a large number of small air bubbles, so that the air bubbles are sufficiently contacted with mineral substances in the ore pulp and the contact possibility is greatly increased; the air bubbles can be selectively adsorbed with ore grains so that high benefits and high efficiency are realized.