The invention discloses a method and a device for manufacturing gasoline with methanol. Raw material methanol is fed into a fluidized bed reactor, contacts with a catalyst and is subjected to a reaction. A reaction product is fed into a gas-liquid separation pot and is subjected to a gas-liquid separation process. Separated gas is fed into a fixed bed reactor, contacts with a catalyst and is subjected to reaction. A reaction product and a discharged liquid are separated in a separation column. The fluidized bed reactor (4) and the fixed bed reactor (11) are communicated with the gas-liquid separation pot (7). The gas-liquid separation pot (7) and the fixed bed reactor (11) are communicated with the separation column (14). By means of the method and the device, gasoline can be obtained in a high yield and a high quality.