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发明公开
CN104117075A 基于金纳米棒多功能探针的核素-切伦科夫发光-CT多模成像方法 失效 - 权利终止

基于金纳米棒多功能探针的核素-切伦科夫发光-CT多模成像方法
摘要：
本发明公开了一种基于金纳米棒多功能探针的核素-切伦科夫发光-CT多模成像方法，将68Ga-AuNRs-RGD多功能分子探针应用于多模态分子成像领域。荷瘤小鼠尾静脉注射68Ga-AuNRs-RGD多功能分子探针，PET/CT成像系统进行核素-CT成像，CLI/CT系统进行切伦科夫发光-CT成像，然后以PET/CT图像作为源图像，以CLI/CT图像作为目标图像，通过灰度配准进行融合，得到了68Ga-AuNRs-RGD多功能分子探针的核素-切伦科夫发光-CT多模态成像显示图。本发明将将68Ga-AuNRs-RGD多功能分子探针应用于多模态分子成像，具有增加光学信号强度、提高成像分辨率、提高成像深度等优点，同时68Ga-AuNRs-RGD多功能分子探针具有分散性良好、毒性低、活细胞膜通透性高等特点。
摘要（英）：

The invention discloses a gold nanorod multifunctional probe-based nuclide-cerenkov luminescence-CT multi-mode imaging method, which applies a <68>Ga-AuNRs-RGD multifunctional molecular probe to the field of multi-mode molecular imaging. The caudal vein of a tumor-bearing mouse is injected with the <68>Ga-AuNRs-RGD multifunctional molecular probe, nuclide-CT imaging is performed by a PET/CT imaging system, cerenkov luminescence-CT imaging is performed by a CLI/CT (cerenkov luminescence imaging/computed tomography) system, and a PET/CT image serving as a source image and a CLI/CT image serving as a target image are fused by means of grey rectification to obtain a nuclide-cerenkov luminescence-CT multi-mode imaging display image based on the <68>Ga-AuNRs-RGD multifunctional molecular probe. According to the method, the <68>Ga-AuNRs-RGD multifunctional molecular probe is applied to multi-mode molecular imaging, has the advantages of increasing optical signal intensity, improving imaging resolution, improving imaging depth and the like, and has the characteristics of excellent dispersion, low toxicity, high living cell membrane permeability and the like.

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