The invention belongs to the technical field of road engineering, and particularly relates to a design method of a hot recycled asphalt mixture with a high RAP proportion. The method comprises the steps of controlling the variability of an RAP material, improving the recycling effect of a recycling agent and determining appropriate test conditions. The design method can effectively increase the blending rate of the RAP, the performance of the recycled asphalt mixture meets the relevant provisions, and the blending ratio of the RAP can reach 36%. According to the design method provided by the invention, the RAP material is well utilized, resources are saved, the waste of materials is avoided, the material cost of highway construction can be effectively reduced, and the damage of resource mining to the environment also can be reduced simultaneously. The economic and environmental advantages of a technology are very obvious.